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The product number for this product was previously 04-12-2723.To obtain a certificate of analysis (CoA) of a lot that begins with the letter A please select the option in the right hand menu Request a COA for Lots starting with A.
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The EasySep™ "Do-It-Yourself" Selection Kit II is designed to select any cell type of interest with your own mouse IgG1 monoclonal antibody. Cells that express the surface antigen that is recognized by the mouse IgG1 monoclonal antibody are targeted for magnetic separation using EasySep™ Dextran RapidSpheres™ and the EasySep™ Magnet.This product replaces the EasySep™ "Do-It-Yourself" Selection Kit (Catalog #18098).
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Streptavidin Mag Sepharose(R) is a magnetic bead for simple and efficient enrichment of target proteins by immunoprecipitation and purification of biotinylated biomolecules. Streptavidin Mag Sepharose(R) utilizes the strong interaction between biotin and streptavidin ligand which is immobilized on magnetic beads. Magnetic beads simplify sample handling in small-scale purifications.
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LILRB4 also known as CD85k and LIR-5 ILT3 is an approximately 60 kDa transmembrane glycoprotein that negatively regulates immune cell activation Mature human ILT3 consists of a 238 amino acid (aa) extracellular domain with two Ig-like domains a 21 aa transmembrane segment and a 168 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM) LILRB4 is receptor for class I MHC antigens Recognizes a broad spectrum of HLA-A HLA-B HLA-C and HLA-G alleles
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An inhibitor of NEDD8-activating enzyme; inhibits NEDDylation of UBC12 in a cell-free assay using recombinant human NAE; selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 cells; inhibits the growth of A549 cells (GI50 = 5.5 µM); inhibits tumor growth in an AGS gastric adenocarcinoma mouse xenograft model at 60 mg/kg
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CD46 was discovered in 1986 during a search for novel C3b-binding proteins CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated self-attack
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